Claudia Fischbach and her lab explore the fields of tissue engineering, microfabrication, and biomaterials strategies to study tumor–microenvironment interaction, particularly mechanical cues and materials properties relevant to breast cancer and bone metastasis, tumor associated vascular niches and angiogenesis.
Damya Laoui’s lab investigates the diversity of populations of myeloid cells in organs and tumors, and the use of these cell populations and their molecular markers as a target for diagnosis and therapeutic interventions during inflammatory diseases and cancer.
As a pioneer of “organ-on-a-chip” technology, Dan Huh and his research group at Penn University focuses on the development of novel bioinspired/biomimetic microsystems that can reproduce integrated structure and function of human organs.
David Mooney | Wyss Institute for Biologically Inspired Engineering, Boston, USA
David Mooney is one of the top leaders in the fields of biomaterials, mechanotransduction, drug delivery, tissue engineering and immuno-engineering. From therapeutic angiogenesis and regeneration of the musculoskeletal tissues, all the way to cancer therapies, a wide spectrum of fields can profit from his cutting-edge research.
Donald E. Ingber | Wyss Institute for Biologically Inspired Engineering, Boston, USA
As a pioneer in the field of biologically inspired engineering, Donald E. Ingber’s work has led to major advances in mechanobiology, tumor angiogenesis, tissue engineering, systems biology, nanobiotechnology, and translational medicine, with his most recent pioneering contribution being the development of human Organ-on-Chips as replacements for animal testing.
Elizabeth Wayne and her lab focuses on using macrophages as tools for diagnostic evaluation and drug delivery carriers in cancer and regenerative medicine. Her research interests cover macrophages, immunoengineering, drug and gene delivery, cancer and biomaterials.
Hanna Isaksson, professor in biomedical technology, is a leader in a research team in biomechanics and mechanobiology focused on skeletal tissues. Her research areas cover primarily bone and tendons biomechanics, and mechanobiology. Her group applies both experimental and computational techniques to help understand the mechanobiology of bones and tendons.
Kai Wucherpfennig studies the mechanisms that constrain the activity of cytotoxic T cells in the tumor microenvironment and identified a series of negative regulators of anti-tumor T cell activity. He is particularly interested in the molecular mechanisms by which these genes inhibit T cell function against tumors to develop novel cancer immunotherapeutic strategies.
As an associate professor, Kara L Spiller is currently conducting research in the design of immunomodulatory biomaterials, particularly for bone tissue engineering. Her research interests include cell-biomaterial interactions, biomaterial design, and international engineering education.
As a professor in Biomedical Engineering, Laoise McNamara’s lab focuses on multidisciplinary techniques to get a better knowledge of bone mechanobiology and how it affects bone formation, function, and disease. Her team uses both experimental and computational methods to pinpoint the particular mechanosensation and mechanotransduction processes that allow bone cells to detect mechanical stimuli.
As a postdoctoral researcher, Lenneke A. M. Cornelissen is investigating the effect of tumor-associated glycan structures on tumor immunity with a focus on understanding the mechanism to develop new cancer immunotherapeutics.
Maksim Mamonkin’s lab investigate the immunobiology of CAR-T cells aiming to develop novel therapies to fight malignant diseases. Along with focusing on CRISPR-engineered CAR-T cells targeting hematologic malignancies, he also explores new opportunities to target pathogenic T cells in immune rejection and autoimmune diseases.
Manuela Gomes research interest focuses on bone, cartilage, and tendon tissue engineering strategies, namely the development of scaffold materials based on biodegradable natural origin polymers and stem cells sourcing and differentiation aiming at developing tissue substitutes.
In Melina Bellin’s lab, they use hPSCs to develop 3D-cardiac microtissue constructs comprising of both cardiomyocytes and non-myocyte cells to reproduce the multicellular organization and the dynamic function of the native heart. From the patient-derived hiPSC to 3D mini hearts development, Belin’s techniques have revolutionized the way we study cardiac diseases.
As a professor of biomedical materials and regenerative medicine, Molly Stevens’ research spans drug delivery, bioactive materials, tissue engineering, biosensing, material characterisation, soft robotics and the interface between living and non-living matter.
Nuri Montserrat’ lab focuses on developind new tools and methodologies for the generation of hPSCs cell lines, derivation of hPSCs-organoids and the formulation of biomimetic materials/bioengineering strategies emulating the tissue milieu particularly heart and kidney tissues.
Sina bartfield’s lab investigates 3D organoids as host models to study pathogenesis. She particularly aims to better understand the human gut, its barrier function, and the interaction with pathogens. Her group uses human stem cell-derived organoids as a model of the human gut and combines technology with approaches such as RNA seq and CRISPR/Cas9 mediates knockout.
As a top leader in the field of cancer immunotherapy as well as cell therapy, Stephen Gottschalk’s research aims at developing novel strategies to reprogram the immune system with a focus on the generation of chimeric antigen receptor (CAR) T cells to fight cancer.